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CS-W001157 4
Total: USD 88.00

5-Amino-1H-indazole

  • CAS No. 19335-11-6

  • Cat. No. CS-W008621
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD00037975

*For research and further manufacturing use only, not for direct human use.

5-Amino-1H-indazole|CS-W008621

Structure of 19335-11-6

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General Information

  • CAS No. 19335-11-6
  • Cat. No. CS-W008621
  • Purity ≥95%
  • MDL No. MFCD00037975
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇N₃
  • Molecular Weight None
  • Synonym(s) 5-Aminoindazole
  • SMILES NC1=CC2=C(NN=C2)C=C1

Description

5-Amino-1H-indazole is a nitrogen-rich heterocyclic scaffold featuring a primary amine at the 5-position, enabling straightforward derivatization. This electron-donating amino group enhances solubility and reactivity in synthetic transformations. The fused bicyclic core imparts metabolic stability and planarity, making it valuable for medicinal chemistry and materials science applications.

Application

5-Amino-1H-indazole serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive heterocycles via standard coupling reactions. Its amino group facilitates derivatization through acylation, alkylation, and transition-metal-catalyzed transformations, while the indazole core exhibits favorable stability and solubility for bench-scale synthesis. Functions effectively in the construction of kinase inhibitors and other pharmaceutical scaffolds.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   1.1451
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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