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CS-W001157 4
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tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate

  • CAS No. 193902-87-3

  • Cat. No. CS-W021302
  • Purity≥97%
  • MDL No.MFCD04117868
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate|CS-W021302

Structure of 193902-87-3

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Description

tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate features a trifluoromethyl-substituted aniline core paired with a piperazine scaffold, enabling efficient integration into bioactive molecules. The tert-butyl ester group offers stability and convenient deprotection under mild acidic conditions, streamlining synthetic workflows in medicinal chemistry.

Application

tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate serves as a key intermediate in the synthesis of bioactive heterocycles, enabling efficient construction of trifluoromethylated phenylpiperazine scaffolds. Its tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The molecule exhibits robust functional group tolerance, supporting diverse coupling reactions and further derivatization in medicinal chemistry campaigns.

General Information

  • CAS No. 193902-87-3
  • Cat. No. CS-W021302
  • Purity ≥97%
  • MDL No. MFCD04117868
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₂F₃N₃O₂
  • Molecular Weight 345.36
  • Synonym(s) 4-(4-AMINO-2-TRIFLUOROMETHYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • SMILES O=C(N1CCN(C2=CC=C(N)C=C2C(F)(F)F)CC1)OC(C)(C)C

Computational Chemistry Data

  • TPSA   58.8
  • LogP   3.3447
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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