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CS-W001157 4
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tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate

  • CAS No. 193902-87-3

  • Cat. No. CS-W021302
  • Molecule weight345.36
  • Purity≥97%
  • MDL No.MFCD04117868

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate|CS-W021302

Structure of 193902-87-3

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General Information

  • CAS No. 193902-87-3
  • Cat. No. CS-W021302
  • Purity ≥97%
  • MDL No. MFCD04117868
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₂F₃N₃O₂
  • Molecular Weight 345.36
  • Synonym(s) 4-(4-AMINO-2-TRIFLUOROMETHYL-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • SMILES O=C(N1CCN(C2=CC=C(N)C=C2C(F)(F)F)CC1)OC(C)(C)C

Description

tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate features a trifluoromethyl-substituted aniline core paired with a piperazine scaffold, enabling efficient integration into bioactive molecules. The tert-butyl ester group offers stability and convenient deprotection under mild acidic conditions, streamlining synthetic workflows in medicinal chemistry.

Application

tert-Butyl 4-(4-amino-2-(trifluoromethyl)phenyl)piperazine-1-carboxylate serves as a key intermediate in the synthesis of bioactive heterocycles, enabling efficient construction of trifluoromethylated phenylpiperazine scaffolds. Its tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The molecule exhibits robust functional group tolerance, supporting diverse coupling reactions and further derivatization in medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.8
  • LogP   3.3447
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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