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CS-W001157 4
Total: USD 88.00

4,4,5,5-Tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane

  • CAS No. 193978-23-3

  • Cat. No. CS-W000892
  • Purity≥97%
  • MDL No.MFCD05663878
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4,4,5,5-Tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane|CS-W000892

Structure of 193978-23-3

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Description

This boronate ester integrates a 2-thienyl group with a tetramethyl-substituted dioxaborolane core, offering enhanced stability and moisture tolerance. The electron-rich thiophene moiety enables efficient coupling in palladium-catalyzed cross-coupling reactions, delivering functionalized heteroaromatics with high reproducibility under standard conditions.

Application

4,4,5,5-Tetramethyl-2-(2-thienyl)-1,3,2-dioxaborolane serves as a stable, bench-ready boron reagent for Suzuki-Miyaura cross-coupling reactions. The 2-thienyl group enables efficient coupling with aryl and heteroaryl halides, facilitating the construction of biaryl and thienyl-containing scaffolds. Its tetramethyl-substituted dioxaborolane core enhances shelf stability and minimizes protodeboronation, while the sterically protected boron center ensures high functional group tolerance and predictable reactivity in standard synthetic workflows.

General Information

  • CAS No. 193978-23-3
  • Cat. No. CS-W000892
  • Purity ≥97%
  • MDL No. MFCD05663878
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅BO₂S
  • Molecular Weight 210.10
  • Synonym(s) 4,4,5,5-tetramethyl-2-thiophen-2-yl-1,3,2-dioxaborolane
  • SMILES CC1(C)OB(OC1(C)C)c1cccs1

Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.0473
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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