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CS-W001157 4
Total: USD 88.00

5-Ethynyl-2-methylpyridine

  • CAS No. 1945-85-3

  • Cat. No. CS-0261503
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-Ethynyl-2-methylpyridine|CS-0261503

Structure of 1945-85-3

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General Information

  • CAS No. 1945-85-3
  • Cat. No. CS-0261503
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇N
  • Molecular Weight 117.15
  • Synonym(s) 5-ethynyl-2-methylpyridine(WXC08791)
  • SMILES C#CC1=CN=C(C)C=C1

Description

5-Ethynyl-2-methylpyridine features a reactive alkyne handle appended to a pyridine core with a methyl group at the ortho position. This configuration enhances electronic modulation and steric accessibility, enabling efficient coupling in transition-metal-catalyzed reactions. The molecule demonstrates robust stability under standard conditions, facilitating straightforward integration into complex molecular architectures.

Application

5-Ethynyl-2-methylpyridine serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted heterocycles via copper-catalyzed coupling reactions. Its conjugated alkyne functionality exhibits excellent stability under standard bench conditions and demonstrates broad compatibility with diverse functional groups. The molecule facilitates straightforward incorporation into complex scaffolds through Sonogashira coupling and other transition-metal-mediated transformations, making it valuable for medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.37132
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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