Lot numbers can be found on the outside label of a product:
(S)-tert-Butyl 2-methylaziridine-1-carboxylate
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CAS No. 197020-60-3
- Cat. No. CS-0079059
- Purity≥98%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 197020-60-3
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General Information
- CAS No. 197020-60-3
- Cat. No. CS-0079059
- Purity ≥98%
- MDL No. None
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₁₅NO₂
- Molecular Weight 157.21
- Synonym(s) tert-butyl (S)-2-methylaziridine-1-carboxylate
- SMILES O=C(OC(C)(C)C)N1[C@@H](C)C1
Description
(S)-tert-Butyl 2-methylaziridine-1-carboxylate features a chiral aziridine core with a methyl group at the 2-position, enabling stereoselective transformations. The tert-butyl carbamate protecting group ensures stability and ease of handling under standard conditions. This bench-stable reagent integrates readily into asymmetric synthesis workflows, delivering controlled ring-opening reactions for complex nitrogen heterocycles.
Application
(S)-tert-Butyl 2-methylaziridine-1-carboxylate serves as a chiral building block for the synthesis of bioactive nitrogen-containing heterocycles. Its strained aziridine ring enables regioselective ring-opening reactions with nucleophiles, facilitating the installation of diverse functional groups under mild conditions. The tert-butyl carbamate group provides excellent stability and ease of removal during late-stage deprotection, enhancing its utility in medicinal chemistry workflows.
Synthesis
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Route1
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In-stock
79069-13-9 - ~82%
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In-stock
197020-60-3
References
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Wessig, Pablo; Schwarz, Jutta Synlett, 1997 , vol. 1997, # 8 p. 893 - 894
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Route2
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126301-16-4 - ~83%
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In-stock
197020-60-3
References
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Adams, David; Benardeau, Agnes; Bickerdike, Mike J.; Bentley, Jon M.; Bissantz, Caterina; Bourson, Anne; Cliffe, Ian A.; Hebeisen, Paul; Kennett, Guy A.; Knight, Antony R.; Malcolm, Craig S.; Mizrahi, Jacques; Plancher, Jean-Marc; Richter, Hans; Roever, Stephan; Taylor, Sven; Vickers, Steven P. Chimia, 2004 , vol. 58, # 9 p. 613 - 620
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Route3
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In-stock
24424-99-5 - ~%
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In-stock
197020-60-3
References
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RANBAXY LABORATORIES LIMITED; DAS, Biswajit; UPADHYAY, Dilip, J.; PURNAPATRE, Kedar; GHOSH, Soma; KATOCH, Rita Patent: WO2012/14109 A1, 2012 ; WO 2012/014109 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅱ
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Hazard Statements : H225-H315-H319
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P362+P364-P370+P378-P501
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Quality Control
Computational Chemistry Data
- TPSA 29.31
- LogP 1.6256
- H_Acceptors 2
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
- 197020-60-3 sigma197020-60-3 manufacturer197020-60-3 price197020-60-3 structure197020-60-3 SDSbuy 197020-60-3197020-60-3 supplier197020-60-3 uses197020-60-3 molecular weightprice of 197020-60-3197020-60-3 chemical name formula of 197020-60-3