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Structure of 197516-57-7
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Methyl 2-Fluoro-6-methylbenzoate features a fluorinated aromatic ring with ortho-fluorine and para-methyl substituents, delivering enhanced electron-withdrawing character and improved metabolic stability. This bench-stable ester integrates readily into synthetic routes requiring polarizable, sterically accessible aryl motifs.
Methyl 2-fluoro-6-methylbenzoate serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the ortho position relative to the ester group. Its fluorine substituent enhances metabolic stability and modulates electronic properties, while the methyl group provides a handle for further oxidation or substitution. The compound exhibits excellent bench stability, facilitates straightforward purification by distillation or chromatography, and participates reliably in palladium-catalyzed cross-coupling reactions, making it a practical choice for constructing complex aromatic scaffolds in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: