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CS-W001157 4
Total: USD 88.00

N-Me-Asp(Otbu)-OH

  • CAS No. 197632-85-2

  • Cat. No. CS-0196954
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

N-Me-Asp(Otbu)-OH|CS-0196954

Structure of 197632-85-2

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General Information

  • CAS No. 197632-85-2
  • Cat. No. CS-0196954
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₇NO₄
  • Molecular Weight 203.24
  • Synonym(s) None
  • SMILES CC(C)(C)OC(=O)C[C@@H](C(=O)O)NC

Description

N-Me-Asp(Otbu)-OH is a sterically hindered, bench-stable amino acid derivative featuring a tert-butyl ester and N-methylated backbone. This configuration enhances resistance to racemization during coupling, enabling reliable incorporation into peptide sequences under standard conditions. The protected side chain facilitates efficient synthesis of complex peptides without interference from carboxylic acid reactivity.

Application

N-Me-Asp(Otbu)-OH serves as a valuable building block in peptide synthesis, offering a stable, bench-ready source of N-methylaspartic acid with orthogonal protection. The OtBu group enables selective deprotection under mild acidic conditions, while the N-methyl substitution enhances metabolic stability and conformational rigidity in bioactive peptides. Its compatibility with standard coupling protocols and resistance to racemization facilitates efficient incorporation into complex sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   0.3908
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   4

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