4-(4-Formylphenyl)piperazine-1-carboxylic acid tert-butyl ester

Name: 4-(4-Formylphenyl)piperazine-1-carboxylic acid tert-butyl ester
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 197638-83-8
Cat. No. CS-W008993
Purity≥97%
MDL No.MFCD05864663

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(4-Formylphenyl)piperazine-1-carboxylic acid tert-butyl ester|CS-W008993

Structure of 197638-83-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 197638-83-8
Cat. No. CS-W008993
Purity ≥97%
MDL No. MFCD05864663
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₂₂N₂O₃
Molecular Weight 290.36
Synonym(s) tert-Butyl 4-(4-formylphenyl)piperazine-1-carboxylate; 1-Boc-4-(4-formylphenyl)piperazine
SMILES O=C(N1CCN(C2=CC=C(C=O)C=C2)CC1)OC(C)(C)C

Description

This piperazine-based building block features a para-formylphenyl moiety and a tert-butyl ester group, enabling straightforward functionalization. The formyl group supports efficient coupling reactions, while the ester provides stability and ease of deprotection under mild conditions.

Application

4-(4-Formylphenyl)piperazine-1-carboxylic acid tert-butyl ester serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. The aldehyde functionality enables efficient reductive amination, Suzuki-Miyaura coupling, or oxime formation, while the tert-butyl ester provides excellent bench stability and orthogonal deprotection under mild acidic conditions. Its compatibility with diverse reaction conditions facilitates rapid scaffold diversification in medicinal chemistry campaigns.

Synthesis

Route1
- 459-57-4
- 57260-71-6
- ~39%
- In-stock
  
  197638-83-8
References
- ACHAOGEN, INC. Patent: WO2008/154642 A2, 2008 ; Location in patent: Page/Page column 155-156 ; WO 2008/154642 A2
Route2
- In-stock
  
  186650-98-6
- ~%
- In-stock
  
  197638-83-8
References
- Chemical and Pharmaceutical Bulletin, , vol. 45, # 9 p. 1458 - 1469

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H317
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 49.85
LogP 2.5562
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Aldehyde

Building Blocks Skeleton Aliphatic heterocycle compounds Piperazine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

197638-83-8 sigma197638-83-8 manufacturer197638-83-8 price197638-83-8 structure197638-83-8 SDSbuy 197638-83-8197638-83-8 supplier197638-83-8 uses197638-83-8 molecular weightprice of 197638-83-8197638-83-8 chemical name formula of 197638-83-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-(4-Formylphenyl)piperazine-1-carboxylic acid tert-butyl ester

CAS No. 197638-83-8

Recommended Products