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CS-W001157 4
Total: USD 88.00

5-Fluoro-2-methoxyaniline

  • CAS No. 1978-39-8

  • Cat. No. CS-W008250
  • Purity≥98%
  • MDL No.MFCD00077537

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methoxyaniline|CS-W008250

Structure of 1978-39-8

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General Information

  • CAS No. 1978-39-8
  • Cat. No. CS-W008250
  • Purity ≥98%
  • MDL No. MFCD00077537
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈FNO
  • Molecular Weight 141.14
  • Synonym(s) 5-Fluoro-o-anisidine
  • SMILES NC1=CC(F)=CC=C1OC

Description

5-Fluoro-2-methoxyaniline features a fluorinated aromatic ring paired with a methoxy group, delivering enhanced electron density and metabolic stability. This combination enables selective coupling in pharmaceutical intermediates, particularly in kinase inhibitor scaffolds and bioactive heterocycles. The molecule exhibits robust bench stability and compatibility with standard amine functionalization protocols.

Application

5-Fluoro-2-methoxyaniline serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via standard coupling reactions. Its ortho-methoxy and meta-fluoro substituents provide complementary reactivity for palladium-catalyzed cross-couplings and electrophilic substitutions, while offering enhanced stability and ease of purification compared to non-substituted analogs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.4165
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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