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Structure of 198203-94-0
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2-Fluoro-3-methoxybenzonitrile features a strategically positioned nitrile group flanked by fluorine and methoxy substituents, delivering enhanced electron-withdrawing character and improved solubility in polar organic media. This combination enables efficient incorporation into complex heterocycles and pharmaceutical intermediates under standard coupling conditions.
2-Fluoro-3-methoxybenzonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the ortho-fluorine site via nucleophilic substitution. The nitrile and methoxy groups provide orthogonal handles for downstream derivatization, while the compound exhibits excellent bench stability and ease of purification. Its compatibility with palladium-catalyzed cross-coupling reactions facilitates efficient access to complex aromatic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: