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CS-W001157 4
Total: USD 88.00

(E)-3-(4-(Trifluoromethoxy)phenyl)acrylic acid

  • CAS No. 199679-35-1

  • Cat. No. CS-0514549
  • Molecule weight232.16
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(E)-3-(4-(Trifluoromethoxy)phenyl)acrylic acid|CS-0514549

Structure of 199679-35-1

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General Information

  • CAS No. 199679-35-1
  • Cat. No. CS-0514549
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇F₃O₃
  • Molecular Weight 232.16
  • Synonym(s) None
  • SMILES FC(F)(F)OC1=CC=C(C=C1)/C=C/C(O)=O

Description

(E)-3-(4-(Trifluoromethoxy)phenyl)acrylic acid features a conjugated enoic acid system linked to an electron-withdrawing trifluoromethoxy group, enhancing its stability and reactivity in cross-coupling and cycloaddition processes. This configuration supports efficient incorporation into bioactive scaffolds and functional materials under standard conditions.

Application

(E)-3-(4-(Trifluoromethoxy)phenyl)acrylic acid serves as a versatile building block for conjugated systems, enabling efficient access to functionalized stilbenes and heterocyclic scaffolds. Its well-defined (E)-configuration ensures synthetic reproducibility, while the trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. The carboxylic acid functionality facilitates direct derivatization or coupling reactions, and the compound exhibits good bench stability and ease of purification in standard organic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.683
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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