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Structure of 37478-58-3
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2-(Piperazin-1-yl)acetic acid features a piperazine ring linked to a carboxylic acid-bearing acetyl side chain, delivering enhanced solubility and hydrogen-bonding capacity. This structural motif enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry scaffolds requiring polar, basic nitrogen centers for target engagement and improved pharmacokinetic profiles.
2-(Piperazin-1-yl)acetic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles and peptide conjugates. Its pendant piperazine moiety offers enhanced solubility and hydrogen-bonding capacity, while the carboxylic acid group facilitates straightforward coupling reactions. The compound exhibits good bench stability and is compatible with standard purification techniques, making it a practical choice for library synthesis and lead optimization workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: