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Structure of 20029-52-1
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4-Cyclohexylbenzoic acid features a rigid, electron-rich aromatic core paired with a bulky cyclohexyl substituent that enhances lipophilicity and steric shielding. This structural combination improves metabolic stability and solubility in organic media, making it suitable for pharmaceutical intermediates and materials synthesis under standard bench conditions.
4-Cyclohexylbenzoic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through standard esterification, amide coupling, and Suzuki-Miyaura cross-coupling reactions. Its rigid aromatic core and lipophilic cyclohexyl substituent enhance metabolic stability and membrane permeability in drug candidates. The carboxylic acid functionality provides excellent handling for purification and derivatization, while the compound exhibits high bench stability and functional group tolerance in multistep syntheses.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P302+P352-P405-P501
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Lot numbers can be found on the outside label of a product: