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Structure of 2022-78-8
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5-Fluoropyrimidin-2(1H)-one is a bench-stable, electron-deficient heterocycle featuring a fluorine atom at the C5 position and a carbonyl group at C2. This structural motif integrates readily into pharmaceutical scaffolds, offering enhanced metabolic stability and targeted hydrogen-bonding interactions in drug design.
5-Fluoropyrimidin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocyclic scaffolds. Its well-established reactivity facilitates nucleophilic substitution at C5 and functionalization at C4, supporting diverse derivatization for drug discovery applications. The compound exhibits good bench stability and compatibility with standard synthetic protocols, simplifying purification and integration into multi-step sequences.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: