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CS-W001157 4
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Benzyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride

  • CAS No. 62147-27-7

  • Cat. No. CS-0127680
  • Molecule weight257.71
  • Purity≥97%
  • MDL No.MFCD00237998

*For research and further manufacturing use only, not for direct human use.

Benzyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride|CS-0127680

Structure of 62147-27-7

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General Information

  • CAS No. 62147-27-7
  • Cat. No. CS-0127680
  • Purity ≥97%
  • MDL No. MFCD00237998
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₆ClNO₃
  • Molecular Weight 257.71
  • Synonym(s) (2S,4R)-Benzyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride
  • SMILES O=C([C@H]1NC[C@H](O)C1)OCC2=CC=CC=C2.[H]Cl

Description

Benzyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride features a stereochemically defined pyrrolidine core with a bench-stable hydroxyl group and a protected carboxylic acid. This configuration enables direct incorporation into peptide-like scaffolds, facilitating the synthesis of bioactive molecules through efficient coupling protocols under standard conditions.

Application

Benzyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride serves as a stereochemically defined building block for the synthesis of bioactive pyrrolidine derivatives. The protected hydroxyl and carboxylate functionalities enable selective transformations in medicinal chemistry workflows. Its bench-stable crystalline form facilitates handling and purification, while the chiral center supports enantioselective synthesis. Functions effectively in peptide-like scaffold construction and heterocyclic derivatization under standard conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.56
  • LogP   0.8744
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   3

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