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CS-W001157 4
Total: USD 88.00

3-Chloro-5-fluorophenol

  • CAS No. 202982-70-5

  • Cat. No. CS-W005519
  • Molecule weight146.55
  • Purity≥95%
  • MDL No.MFCD00042212

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-fluorophenol|CS-W005519

Structure of 202982-70-5

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General Information

  • CAS No. 202982-70-5
  • Cat. No. CS-W005519
  • Purity ≥95%
  • MDL No. MFCD00042212
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClFO
  • Molecular Weight 146.55
  • Synonym(s) None
  • SMILES ClC1=CC(F)=CC(O)=C1

Description

3-Chloro-5-fluorophenol features a phenolic hydroxyl group flanked by chlorine and fluorine substituents, delivering enhanced electron-withdrawal and metabolic stability. This combination enables selective reactivity in pharmaceutical intermediates and agrochemical synthesis, particularly in coupling reactions requiring halogen-directed functionalization.

Application

3-Chloro-5-fluorophenol serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling selective functionalization at the phenolic hydroxyl group. Its electron-withdrawing halogen substituents enhance reactivity in nucleophilic aromatic substitution and facilitate coupling reactions via Pd-catalyzed cross-coupling protocols. The compound exhibits good bench stability and is compatible with common protecting group strategies, supporting efficient route design for complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   2.1847
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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