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CS-W001157 4
Total: USD 88.00

2-[4-(Trifluoromethyl)phenyl]pyridine

  • CAS No. 203065-88-7

  • Cat. No. CS-0085937
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-[4-(Trifluoromethyl)phenyl]pyridine|CS-0085937

Structure of 203065-88-7

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General Information

  • CAS No. 203065-88-7
  • Cat. No. CS-0085937
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₈F₃N
  • Molecular Weight 223.19
  • Synonym(s) 2-(4-TRIFLUOROMETHYLPHENYL)PYRIDINE
  • SMILES FC(F)(F)C1=CC=C(C=C1)C2=NC=CC=C2

Description

2-[4-(Trifluoromethyl)phenyl]pyridine features a rigid, electron-deficient pyridine core conjugated to a trifluoromethyl-substituted phenyl ring, enhancing its stability and enabling effective coordination in transition metal catalysis. This structure supports efficient ligand design for palladium- and copper-mediated cross-coupling reactions.

Application

2-[4-(Trifluoromethyl)phenyl]pyridine serves as a versatile building block in medicinal chemistry and catalysis, leveraging the combined electronic effects of the pyridine and trifluoromethylaryl moieties. Its robust stability, compatibility with cross-coupling reactions, and utility in constructing bioactive heterocyclic scaffolds make it a reliable component in drug discovery workflows.

Synthesis

  • Route1
    • null|null
      109-04-6
    • In-stock
      4-Trifluoromethylphenylboronic acid|CS-W008762
      128796-39-4
    • ~73%
    • In-stock
      2-[4-(Trifluoromethyl)phenyl]pyridine|CS-0085937
      203065-88-7

    References

    • Xu, Qiu-Lei; Wang, Cheng-Cheng; Li, Tian-Yi; Teng, Ming-Yu; Zhang, Song; Jing, Yi-Ming; Yang, Xu; Li, Wei-Nan; Lin, Chen; Zheng, You-Xuan; Zuo, Jing-Lin; You, Xiao-Zeng Inorganic Chemistry, 2013 , vol. 52, # 9 p. 4916 - 4925
  • Route2
    • null|null
      109-09-1
    • null|null
      98-56-6
    • ~84%
    • In-stock
      2-[4-(Trifluoromethyl)phenyl]pyridine|CS-0085937
      203065-88-7

    References

    • Gosmini, Corinne; Bassene-Ernst, Carine; Durandetti, Muriel Tetrahedron, 2009 , vol. 65, # 31 p. 6141 - 6146
  • Route3
    • null|null
      109-04-6
    • In-stock
      1-Bromo-4-(trifluoromethyl)benzene|CS-W014220
      402-43-7
    • ~77%
    • In-stock
      2-[4-(Trifluoromethyl)phenyl]pyridine|CS-0085937
      203065-88-7

    References

    • Gosmini, Corinne; Bassene-Ernst, Carine; Durandetti, Muriel Tetrahedron, 2009 , vol. 65, # 31 p. 6141 - 6146

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.7674
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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