tert-Butyl 4-amino-4-(hydroxymethyl)piperidine-1-carboxylate

Name: tert-Butyl 4-amino-4-(hydroxymethyl)piperidine-1-carboxylate
Brand: ChemScene
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CAS No. 203186-96-3
Cat. No. CS-0036461
Purity≥97%
MDL No.MFCD11845683

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl 4-amino-4-(hydroxymethyl)piperidine-1-carboxylate|CS-0036461

Structure of 203186-96-3

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General Information

CAS No. 203186-96-3
Cat. No. CS-0036461
Purity ≥97%
MDL No. MFCD11845683
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₂₂N₂O₃
Molecular Weight 230.30
Synonym(s) None
SMILES CC(C)(OC(N1CCC(CO)(N)CC1)=O)C

Description

tert-Butyl 4-amino-4-(hydroxymethyl)piperidine-1-carboxylate is a versatile piperidine-based building block featuring a primary amine and a hydroxymethyl group on the same ring. This combination enables direct functionalization at both sites, facilitating the synthesis of complex nitrogen-containing scaffolds in medicinal chemistry and peptide derivatization. The tert-butyl carbamate protects the amine under standard conditions while allowing selective deprotection when needed.

Application

tert-Butyl 4-amino-4-(hydroxymethyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The pendant hydroxymethyl group facilitates downstream functionalization via oxidation or derivatization, while the protected amine allows for selective transformations. Its bench-stable nature and compatibility with standard coupling and reduction protocols make it ideal for multi-step synthesis of bioactive molecules.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 75.79
LogP 0.7071
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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tert-Butyl 4-amino-4-(hydroxymethyl)piperidine-1-carboxylate

CAS No. 203186-96-3

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