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CS-W001157 4
Total: USD 88.00

1-Chloro-2-iodo-3-(trifluoromethyl)benzene

  • CAS No. 203626-41-9

  • Cat. No. CS-0028336
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Chloro-2-iodo-3-(trifluoromethyl)benzene|CS-0028336

Structure of 203626-41-9

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Description

1-Chloro-2-iodo-3-(trifluoromethyl)benzene features a trifluoromethyl group flanked by orthogonal halogens, enabling selective cross-coupling in late-stage functionalization. This electron-deficient aryl scaffold integrates seamlessly into pharmaceutical and agrochemical scaffolds, offering enhanced metabolic stability and tailored lipophilicity.

Application

1-Chloro-2-iodo-3-(trifluoromethyl)benzene serves as a versatile diaryl building block for palladium-catalyzed cross-coupling reactions. The orthogonal reactivity of chlorine and iodine enables sequential functionalization, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. Bench-stable and compatible with standard coupling conditions, it facilitates efficient construction of complex biaryl scaffolds and heterocyclic systems relevant to pharmaceutical development.

General Information

  • CAS No. 203626-41-9
  • Cat. No. CS-0028336
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃ClF₃I
  • Molecular Weight 306.45
  • Synonym(s) 3-CHLORO-2-IODOBENZOTRIFLUORIDE
  • SMILES FC(F)(C1=C(C(Cl)=CC=C1)I)F

Computational Chemistry Data

  • TPSA   0
  • LogP   3.9634
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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