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Structure of 20372-63-8
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4,5-Difluoro-2-nitrobenzoic acid features a highly electron-deficient aromatic core enhanced by two fluorine substituents and a nitro group at the ortho position. This combination enables robust coupling reactions under mild conditions, while the carboxylic acid moiety facilitates direct derivatization. The molecule exhibits excellent stability and solubility in common organic solvents, making it ideal for synthetic intermediates in pharmaceutical and agrochemical development.
4,5-Difluoro-2-nitrobenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated aromatic motifs into bioactive scaffolds. Its dual electron-withdrawing nitro and carboxylic acid groups enhance electrophilicity for nucleophilic aromatic substitution and facilitate coupling reactions via standard amide bond formation. The difluoro substitution pattern improves metabolic stability and modulates electronic properties, while the compound exhibits sufficient bench stability for routine handling and purification.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: