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Structure of 83506-93-8
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2-Amino-4,5-difluorobenzoic acid features a strategically positioned amino group flanked by two fluorine substituents, delivering enhanced electron-withdrawing effects and improved metabolic stability. This combination enables direct incorporation into bioactive scaffolds, particularly in pharmaceutical intermediates where orthogonal reactivity and solubility are critical.
2-Amino-4,5-difluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive scaffolds. Its dual functionality—amine and carboxylic acid—facilitates diverse coupling reactions, including amide formation and cyclization pathways. The difluoro substitution enhances metabolic stability and modulates electronic properties, while the compound exhibits good bench stability and ease of purification, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: