N-Boc-4,4-difluoro-L-proline

Name: N-Boc-4,4-difluoro-L-proline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 203866-15-3
Cat. No. CS-W004000
Purity≥96%
MDL No.MFCD03094917

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 203866-15-3

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Application

N-Boc-4,4-difluoro-L-proline serves as a conformationally constrained building block for peptide synthesis, leveraging the rigidity of the proline scaffold enhanced by geminal difluorination. The Boc group provides stable protection under standard deprotection conditions, while the 4,4-difluoro substitution improves metabolic stability and modulates electronic properties. This derivative facilitates efficient incorporation into peptidomimetics and macrocyclic scaffolds, enabling precise control over backbone geometry in medicinal chemistry campaigns.

General Information

CAS No. 203866-15-3
Cat. No. CS-W004000
Purity ≥96%
MDL No. MFCD03094917
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₅F₂NO₄
Molecular Weight 251.23
Synonym(s) N-(tert-Butoxycarbonyl)-4,4-difluoro-L-proline
SMILES O=C(N1CC(C[C@H]1C(=O)O)(F)F)OC(C)(C)C

Computational Chemistry Data

TPSA 66.84
LogP 1.7157
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Key Words

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N-Boc-4,4-difluoro-L-proline

CAS No. 203866-15-3

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