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(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methylhexanoic acid

  • CAS No. 204320-60-5

  • Cat. No. CS-0120010
  • Purity≥98%
  • MDL No.MFCD00270205

*For research and further manufacturing use only, not for direct human use.

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methylhexanoic acid|CS-0120010

Structure of 204320-60-5

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General Information

  • CAS No. 204320-60-5
  • Cat. No. CS-0120010
  • Purity ≥98%
  • MDL No. MFCD00270205
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₅NO₄
  • Molecular Weight 367.44
  • Synonym(s) Fmoc-D-homoleucine
  • SMILES CC(C)CC[C@H](C(O)=O)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methylhexanoic acid is a chiral amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group. This configuration enables efficient incorporation into peptide synthesis workflows, offering excellent solubility and stability under standard coupling conditions. The branched alkyl side chain enhances hydrophobicity, supporting structural diversity in peptidomimetic design.

Application

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-methylhexanoic acid serves as a robust chiral building block for peptide synthesis, enabling efficient N-terminal protection with orthogonal deprotection under mild conditions. The Fmoc group ensures high stability during standard coupling protocols and facilitates clean removal via base-mediated cleavage. Its branched alkyl side chain provides steric differentiation and enhances solubility in organic solvents, supporting reliable purification and scalability in both solution-phase and solid-phase workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   4.4145
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   7

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