Fmoc-N-Me-Asp(OMe)-OH

Name: Fmoc-N-Me-Asp(OMe)-OH
Brand: ChemScene
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CAS No. 2044710-58-7
Cat. No. CS-0439302
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-N-Me-Asp(OMe)-OH is a protected aspartic acid derivative designed for efficient solid-phase peptide synthesis. The Fmoc group enables orthogonal deprotection, while the N-methyl and methyl ester functionalities enhance solubility and reduce racemization risk. This variant offers improved handling and incorporation fidelity in complex sequence assembly.

Application

Fmoc-N-Me-Asp(OMe)-OH serves as a valuable building block in peptide synthesis, offering enhanced stability and reduced racemization during coupling. The Fmoc group enables efficient orthogonal deprotection, while the N-methylated amine minimizes unwanted side reactions. The methyl ester facilitates straightforward conversion to carboxylic acid or amide derivatives, supporting versatile functionalization in solid-phase and solution-phase workflows.

General Information

CAS No. 2044710-58-7
Cat. No. CS-0439302
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₂₁NO₆
Molecular Weight 383.39
Synonym(s) (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4-methoxy-4-oxobutanoic acid
SMILES C(OC(N([C@@H](CC(OC)=O)C(O)=O)C)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Computational Chemistry Data

TPSA 93.14
LogP 2.8836
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Aspartic acid and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-N-Me-Asp(OMe)-OH

CAS No. 2044710-58-7

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