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CS-W001157 4
Total: USD 88.00

N-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamine

  • CAS No. 204580-28-9

  • Cat. No. CS-0154942
  • Purity≥96%
  • MDL No.MFCD20662141
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

N-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamine|CS-0154942

Structure of 204580-28-9

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Description

N-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamine features a silyl-protected hydroxyl group paired with a primary amine, enabling orthogonal functionalization in complex synthesis. This bench-stable derivative facilitates selective deprotection and coupling workflows, particularly in oligonucleotide and peptide conjugation strategies where stability and regioselective reactivity are critical.

Application

N-[2-(tert-Butyldimethylsilyloxy)ethyl]methylamine serves as a versatile silyl-protected amine building block, enabling selective functionalization in complex molecule synthesis. The tert-butyldimethylsilyl (TBS) group provides robust protection under standard conditions, with high stability toward nucleophiles and mild acidic/basic environments. It facilitates orthogonal handling in multi-step sequences, allowing controlled deprotection via fluoride sources. Its methylamino functionality supports direct coupling or derivatization, making it ideal for peptide analogs, agrochemical intermediates, and pharmaceutical scaffolds requiring reliable protection strategies.

General Information

  • CAS No. 204580-28-9
  • Cat. No. CS-0154942
  • Purity ≥96%
  • MDL No. MFCD20662141
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₂₃NOSi
  • Molecular Weight 189.37
  • Synonym(s) None
  • SMILES CC(C)(C)[Si](C)(C)OCCNC

Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.2276
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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