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CS-W001157 4
Total: USD 88.00

tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate

  • CAS No. 205059-24-1

  • Cat. No. CS-0084601
  • Molecule weight269.39
  • Purity≥95%
  • MDL No.MFCD04974009

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate|CS-0084601

Structure of 205059-24-1

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General Information

  • CAS No. 205059-24-1
  • Cat. No. CS-0084601
  • Purity ≥95%
  • MDL No. MFCD04974009
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₇N₃O₂
  • Molecular Weight 269.39
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CCN(CC1)C2CCNCC2

Application

tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to complex piperidine-containing scaffolds. The tert-butyl carbamate group provides excellent stability and ease of removal under mild acidic conditions, while the piperazine core offers multiple sites for derivatization. It functions effectively in standard coupling reactions and facilitates the construction of bioactive heterocycles with high functional group tolerance and predictable reactivity profiles.

Synthesis

  • Route1
    • null|null
      205059-23-0
    • ~93%
    • In-stock
      tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate|CS-0084601
      205059-24-1

    References

    • SCHERING CORPORATION Patent: US2004/138226 A1, 2004 ; Location in patent: Page 22 ;
  • Route2
    • null|null
      926904-28-1
    • ~86%
    • In-stock
      tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate|CS-0084601
      205059-24-1

    References

    • MERCK PATENT GMBH; SCHIEMANN, Kai; SCHULTZ, Melanie; STAEHLE, Wolfgang Patent: WO2010/115491 A2, 2010 ; Location in patent: Page/Page column 84-85 ; WO 2010/115491 A2
  • Route3
    • null|null
      939983-24-1
    • ~%
    • In-stock
      tert-Butyl 4-(piperidin-4-yl)piperazine-1-carboxylate|CS-0084601
      205059-24-1

    References

    • US2007/129416 A1, ; Page/Page column 21/1 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P234-P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P312-P332+P313-P362+P364-P390-P403+P233-P405-P406-P501

Quality Control

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Computational Chemistry Data

  • TPSA   44.81
  • LogP   1.2911
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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