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CS-W001157 4
Total: USD 88.00

4-Chloro-6-methoxyquinolin-7-ol

  • CAS No. 205448-31-3

  • Cat. No. CS-W006640
  • Purity≥98%
  • MDL No.MFCD13191788
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Chloro-6-methoxyquinolin-7-ol|CS-W006640

Structure of 205448-31-3

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Description

4-Chloro-6-methoxyquinolin-7-ol features a quinoline scaffold with strategic electron-withdrawing and donor substituents, enabling its use in cross-coupling reactions and as a building block for bioactive heterocycles. The chloro group at C4 facilitates palladium-catalyzed transformations, while the methoxy and hydroxyl functionalities provide sites for further functionalization. This compound exhibits good stability under standard handling conditions.

Application

4-Chloro-6-methoxyquinolin-7-ol serves as a versatile building block in medicinal chemistry, enabling efficient construction of quinoline-based scaffolds. Its orthogonal functional groups—chloro at C4, methoxy at C6, and phenolic hydroxyl at C7—facilitate diverse transformations including Suzuki-Miyaura coupling, nucleophilic substitution, and directed metalation. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.

General Information

  • CAS No. 205448-31-3
  • Cat. No. CS-W006640
  • Purity ≥98%
  • MDL No. MFCD13191788
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₈ClNO₂
  • Molecular Weight 209.63
  • Synonym(s) 7-Quinolinol,4-chloro-6-methoxy-
  • SMILES ClC1=CC=NC2=CC(=C(C=C12)OC)O

Computational Chemistry Data

  • TPSA   42.35
  • LogP   2.6024
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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