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Structure of 2055033-05-9
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Mal-PEG8-NHS ester is a bifunctional crosslinker featuring a maleimide group and a reactive NHS ester, separated by an 8-unit PEG spacer. This design enables efficient conjugation to thiol-containing biomolecules and amine-functionalized surfaces under physiological conditions. The hydrophilic PEG chain minimizes non-specific binding and enhances solubility in aqueous environments.
Mal-PEG8-NHS ester serves as a versatile bifunctional linker for site-specific conjugation, combining the reactive maleimide group with a hydrophilic PEG8 spacer and an NHS ester for amine coupling. It enables efficient, orthogonal bioconjugation in aqueous conditions, offering enhanced stability and reduced aggregation compared to shorter PEG chains. Ideal for antibody-drug conjugate (ADC) synthesis and protein labeling, it facilitates reliable conjugation with minimal side reactions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: