Fmoc-D-Phe(4-CN)-OH

Name: Fmoc-D-Phe(4-CN)-OH
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 205526-34-7
Cat. No. CS-W011673
Purity≥98%
MDL No.MFCD00672560

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 205526-34-7

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Description

Fmoc-D-Phe(4-CN)-OH features a para-cyanophenyl side chain on the D-phenylalanine scaffold, offering enhanced electron-withdrawing character for improved coupling efficiency. This bench-stable derivative integrates seamlessly into solid-phase peptide synthesis workflows, enabling precise incorporation of D-Phe residues with defined electronic properties.

Application

Fmoc-D-Phe(4-CN)-OH serves as a valuable building block in peptide synthesis, offering enhanced stability and orthogonal handling in solid-phase workflows. The 4-cyanophenyl side chain provides a robust platform for downstream functionalization via nucleophilic substitution or transition-metal-catalyzed coupling. Its bench-stable Fmoc protection enables reliable deprotection under standard conditions, while the D-configuration imparts conformational rigidity useful in bioactive peptide design.

General Information

CAS No. 205526-34-7
Cat. No. CS-W011673
Purity ≥98%
MDL No. MFCD00672560
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₀N₂O₄
Molecular Weight 412.44
Synonym(s) None
SMILES O=C([C@@H](CC1=CC=C(C=C1)C#N)NC(OCC2C3=C(C=CC=C3)C4=C2C=CC=C4)=O)O

Computational Chemistry Data

TPSA 99.42
LogP 4.09268
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Bioactive Molecules Peptides

Building Blocks Functional Group Fmoc

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-D-Phe(4-CN)-OH

CAS No. 205526-34-7

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