tert-Butyl (3S)-3-amino-4,4-difluoropiperidine-1-carboxylate

Name: tert-Butyl (3S)-3-amino-4,4-difluoropiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
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CAS No. 2055848-75-2
Cat. No. CS-0048544
Purity≥98%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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tert-Butyl (3S)-3-amino-4,4-difluoropiperidine-1-carboxylate|CS-0048544

Structure of 2055848-75-2

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Description

This tert-butyl (3S)-3-amino-4,4-difluoropiperidine-1-carboxylate features a stereochemically defined piperidine core with dual fluorine atoms at the 4-position, enhancing metabolic stability and membrane permeability. The tert-butoxycarbonyl group provides protection for the amine, enabling straightforward incorporation into peptide sequences or small molecule scaffolds under standard conditions.

Application

tert-Butyl (3S)-3-amino-4,4-difluoropiperidine-1-carboxylate serves as a stereochemically defined building block for the synthesis of fluorinated piperidine scaffolds prevalent in medicinal chemistry. The 4,4-difluoro substitution enhances metabolic stability and modulates basicity, while the tert-butyl carbamate group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. This compound enables efficient incorporation into complex molecular architectures via standard coupling reactions and functional group interconversions.

General Information

CAS No. 2055848-75-2
Cat. No. CS-0048544
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈F₂N₂O₂
Molecular Weight 236.26
Synonym(s) None
SMILES CC(C)(C)OC(=O)N1CCC(F)(F)[C@@H](N)C1

Computational Chemistry Data

TPSA 55.56
LogP 1.5898
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

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tert-Butyl (3S)-3-amino-4,4-difluoropiperidine-1-carboxylate

CAS No. 2055848-75-2

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