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CS-W001157 4
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Tos-PEG3-NH-Boc

  • CAS No. 206265-94-3

  • Cat. No. CS-0100060
  • Purity≥98%
  • MDL No.MFCD31543976

*For research and further manufacturing use only, not for direct human use.

Tos-PEG3-NH-Boc|CS-0100060

Structure of 206265-94-3

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General Information

  • CAS No. 206265-94-3
  • Cat. No. CS-0100060
  • Purity ≥98%
  • MDL No. MFCD31543976
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₈H₂₉NO₇S
  • Molecular Weight 403.49
  • Synonym(s) PROTAC Linker 9
  • SMILES CC1=CC=C(S(OCCOCCOCCNC(OC(C)(C)C)=O)(=O)=O)C=C1

Description

Tos-PEG3-NH-Boc features a triethylene glycol spacer flanked by a tosyl-activated amine and a Boc-protected nitrogen, enabling sequential conjugation in peptide and biomolecule synthesis. This bifunctional linker combines solubility, stability, and orthogonal reactivity for efficient coupling workflows.

Application

Tos-PEG3-NH-Boc serves as a versatile bifunctional building block for peptide and oligonucleotide conjugation, combining a tosyl (Tos) leaving group with a PEG3 spacer and a Boc-protected amine. The Tos group enables efficient nucleophilic substitution under mild conditions, while the PEG3 chain enhances solubility and reduces aggregation. The Boc-protected amine allows for selective deprotection and further functionalization, facilitating modular synthesis of bioconjugates and drug delivery systems.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   100.16
  • LogP   2.25822
  • H_Acceptors   7
  • H_Donors   1
  • Rotatable_Bonds   11

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