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CS-W001157 4
Total: USD 88.00

Tos-PEG2-NH-Boc

  • CAS No. 192132-77-7

  • Cat. No. CS-0114150
  • Purity≥98%
  • MDL No.MFCD28506265
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Tos-PEG2-NH-Boc|CS-0114150

Structure of 192132-77-7

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Description

Tos-PEG2-NH-Boc features a bis(tert-butoxycarbonyl)amino terminus linked via a short PEG spacer to a tosyl group, enabling dual protection for amine functionalities. This bifunctional reagent integrates seamlessly into peptide synthesis workflows, offering orthogonal handling and controlled deprotection under mild conditions.

Application

Tos-PEG2-NH-Boc serves as a versatile bifunctional building block for peptide and oligonucleotide conjugation, combining a tosyl (Tos) leaving group with a PEG2 spacer and a Boc-protected amine. The Tos group enables efficient nucleophilic substitution with amines or thiols, while the PEG2 spacer enhances solubility and reduces aggregation. The Boc-protected amine offers orthogonal handling in multi-step syntheses, facilitating selective deprotection and coupling under standard conditions. This reagent supports reliable functionalization in solid-phase and solution-phase workflows.

General Information

  • CAS No. 192132-77-7
  • Cat. No. CS-0114150
  • Purity ≥98%
  • MDL No. MFCD28506265
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₆H₂₅NO₆S
  • Molecular Weight 359.44
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)NCCOCCOS(=O)(C1=CC=C(C)C=C1)=O

Computational Chemistry Data

  • TPSA   90.93
  • LogP   2.24162
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   8

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331-H341
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P405-P501

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