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CS-W001157 4
Total: USD 88.00

5-Chloro-3-fluoropicolinic acid

  • CAS No. 207994-08-9

  • Cat. No. CS-0132621
  • Purity≥98%
  • MDL No.MFCD12827555

*For research and further manufacturing use only, not for direct human use.

5-Chloro-3-fluoropicolinic acid|CS-0132621

Structure of 207994-08-9

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General Information

  • CAS No. 207994-08-9
  • Cat. No. CS-0132621
  • Purity ≥98%
  • MDL No. MFCD12827555
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃ClFNO₂
  • Molecular Weight 175.54
  • Synonym(s) 5-Chloro-3-fluoropyridine-2-carboxylic acid
  • SMILES O=C(C1=NC=C(Cl)C=C1F)O

Description

5-Chloro-3-fluoropicolinic acid features a strategically positioned chloro and fluoro substituent on the picolinic acid scaffold, enhancing electron deficiency and metabolic stability. This configuration supports direct incorporation into heterocyclic scaffolds, enabling efficient access to bioactive compounds in medicinal chemistry and agrochemical development.

Application

5-Chloro-3-fluoropicolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-halogenated pyridine core facilitates palladium-catalyzed cross-coupling reactions, while the carboxylic acid group supports direct derivatization or amide formation. The molecule exhibits excellent bench stability and compatibility with diverse functional groups, making it ideal for iterative synthesis workflows.

Synthesis

  • Route1
    • null|null
      124-38-9
    • In-stock
      5-Chloro-3-fluoro-2-iodopyridine|CS-0173258
      514797-98-9
    • ~96%
    • In-stock
      5-Chloro-3-fluoropicolinic acid|CS-0132621
      207994-08-9

    References

    • European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
  • Route2
    • null|null
      124-38-9
    • In-stock
      2-Bromo-5-chloro-3-fluoropyridine|CS-W021618
      514797-97-8
    • ~73%
    • In-stock
      5-Chloro-3-fluoropicolinic acid|CS-0132621
      207994-08-9

    References

    • European Journal of Organic Chemistry, , # 24 p. 4174 - 4180
  • Route3

    References

    • European Journal of Organic Chemistry, , # 24 p. 4174 - 4180

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.5723
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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