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Structure of 209328-87-0
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2-Fluoro-6-methylpyridin-3-ol features a strategically positioned fluorine atom and methyl group on a pyridinol scaffold, delivering enhanced electron-withdrawing character and improved metabolic stability. This configuration supports efficient coupling in cross-coupling reactions and enables selective functionalization in pharmaceutical intermediates.
2-Fluoro-6-methylpyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridin-3-ol site for Suzuki-Miyaura and Buchwald-Hartwig couplings. Its fluorine and methyl groups provide orthogonal reactivity and enhanced metabolic stability, while the phenolic hydroxyl facilitates protection and derivatization. Bench-stable and readily purified by recrystallization, it functions efficiently in multi-step synthesis of heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: