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CS-W001157 4
Total: USD 88.00

Pomalidomide-PEG4-C-COOH

  • CAS No. 2097938-44-6

  • Cat. No. CS-B1583
  • Purity≥95%
  • MDL No.MFCD31540390

*For research and further manufacturing use only, not for direct human use.

Pomalidomide-PEG4-C-COOH|CS-B1583

Structure of 2097938-44-6

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General Information

  • CAS No. 2097938-44-6
  • Cat. No. CS-B1583
  • Purity ≥95%
  • MDL No. MFCD31540390
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₉N₃O₁₀
  • Molecular Weight 507.49
  • Synonym(s) Cereblon Ligand -Linker Conjugates 1; E3 Ligase Ligand-Linker Conjugates 1
  • SMILES O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3NCCOCCOCCOCCOCC(O)=O

Description

Pomalidomide-PEG4-C-COOH integrates a PEG4 spacer with a terminal carboxylic acid, enabling efficient conjugation to biomolecules or solid supports. This derivative retains the pharmacological profile of pomalidomide while enhancing solubility and facilitating site-specific bioconjugation in drug delivery and chemical biology applications.

Application

Pomalidomide-PEG4-C-COOH serves as a versatile bifunctional linker for conjugate development, combining the immunomodulatory properties of pomalidomide with a stable PEG4 spacer and terminal carboxylic acid. The structure enables site-specific bioconjugation via amide bond formation, facilitating targeted delivery in antibody-drug or PROTAC architectures. Bench-stable and compatible with standard coupling conditions, it supports efficient purification and predictable pharmacokinetic behavior in preclinical applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   169.8
  • LogP   -0.3493
  • H_Acceptors   10
  • H_Donors   3
  • Rotatable_Bonds   16

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