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CS-W001157 4
Total: USD 88.00

Pomalidomide-PEG4-C-COOH

  • CAS No. 2097938-44-6

  • Cat. No. CS-B1583
  • Purity≥95%
  • MDL No.MFCD31540390
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Pomalidomide-PEG4-C-COOH|CS-B1583

Structure of 2097938-44-6

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Description

Pomalidomide-PEG4-C-COOH integrates a PEG4 spacer with a terminal carboxylic acid, enabling efficient conjugation to biomolecules or solid supports. This derivative retains the pharmacological profile of pomalidomide while enhancing solubility and facilitating site-specific bioconjugation in drug delivery and chemical biology applications.

Application

Pomalidomide-PEG4-C-COOH serves as a versatile bifunctional linker for conjugate development, combining the immunomodulatory properties of pomalidomide with a stable PEG4 spacer and terminal carboxylic acid. The structure enables site-specific bioconjugation via amide bond formation, facilitating targeted delivery in antibody-drug or PROTAC architectures. Bench-stable and compatible with standard coupling conditions, it supports efficient purification and predictable pharmacokinetic behavior in preclinical applications.

General Information

  • CAS No. 2097938-44-6
  • Cat. No. CS-B1583
  • Purity ≥95%
  • MDL No. MFCD31540390
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₉N₃O₁₀
  • Molecular Weight 507.49
  • Synonym(s) Cereblon Ligand -Linker Conjugates 1; E3 Ligase Ligand-Linker Conjugates 1
  • SMILES O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3NCCOCCOCCOCCOCC(O)=O

Computational Chemistry Data

  • TPSA   169.8
  • LogP   -0.3493
  • H_Acceptors   10
  • H_Donors   3
  • Rotatable_Bonds   16

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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