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Structure of 21005-45-8
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1-Methyl-1H-indole-6-carbaldehyde features a methyl-substituted indole core paired with an aldehyde group at the C6 position, enabling direct incorporation into diverse synthetic scaffolds. This electron-rich heterocycle delivers enhanced solubility and reactivity in transition-metal-catalyzed coupling reactions, particularly under mild conditions. The pendant aldehyde serves as a key handle for derivatization via reductive amination or Wittig-type transformations. Bench-stable and moisture-tolerant, it streamlines access to functionalized indole-based libraries for medicinal chemistry applications.
1-Methyl-1H-indole-6-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the indole C6 position. Its aldehyde functionality facilitates efficient imine formation, reductive amination, and Staudinger ligation, while the methyl group enhances metabolic stability. The compound exhibits excellent bench stability and compatibility with common protecting groups, facilitating straightforward purification and integration into multi-step syntheses of heterocyclic scaffolds and API candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H319-H412
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Precautionary Statements : P264-P273-P280-P501
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Lot numbers can be found on the outside label of a product: