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CS-W001157 4
Total: USD 88.00

4-Hydroxy-3,4-dihydronaphthalen-1(2H)-one

  • CAS No. 21032-12-2

  • Cat. No. CS-W022192
  • Purity≥97%
  • MDL No.MFCD11036279

*For research and further manufacturing use only, not for direct human use.

4-Hydroxy-3,4-dihydronaphthalen-1(2H)-one|CS-W022192

Structure of 21032-12-2

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General Information

  • CAS No. 21032-12-2
  • Cat. No. CS-W022192
  • Purity ≥97%
  • MDL No. MFCD11036279
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₂
  • Molecular Weight 162.19
  • Synonym(s) 4-Tetralol-1-one
  • SMILES O=C1CCC(O)C2=C1C=CC=C2

Description

4-Hydroxy-3,4-dihydronaphthalen-1(2H)-one features a fused bicyclic core with a phenolic hydroxyl and ketone functionality, enabling direct participation in hydrogen bonding and electrophilic reactions. This scaffold serves as a key intermediate in natural product synthesis and offers enhanced solubility in polar solvents compared to fully aromatic analogs.

Application

4-Hydroxy-3,4-dihydronaphthalen-1(2H)-one serves as a versatile scaffold in synthetic organic chemistry, enabling access to functionalized naphthalene derivatives through controlled oxidation and substitution reactions. Its fused ring system exhibits bench stability and compatibility with standard protecting group strategies, facilitating downstream transformations in medicinal chemistry and natural product synthesis.

Synthesis

  • Route1
    • null|null
      153259-54-2
    • ~94%
    • In-stock
      4-Hydroxy-3,4-dihydronaphthalen-1(2H)-one|CS-W022192
      21032-12-2

    References

    • Joly; Nair, Mangalam S. Tetrahedron Asymmetry, 2001 , vol. 12, # 16 p. 2283 - 2287
  • Route2

    References

    • Feldberg, Liron; Sasson, Yoel Tetrahedron Letters, 1996 , vol. 37, # 12 p. 2063 - 2066
  • Route3

    References

    • Watanabe, Yoshihito; Ishimura, Yuzuru Journal of the American Chemical Society, 1989 , vol. 111, # 1 p. 410 - 411

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.6965
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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