Mal-amido-PEG2-Val-Cit-PAB-PNP

Name: Mal-amido-PEG2-Val-Cit-PAB-PNP
Brand: ChemScene
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CAS No. 2112738-13-1
Cat. No. CS-0115252
Purity≥98%
MDL No.MFCD30828687

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Mal-amido-PEG2-Val-Cit-PAB-PNP|CS-0115252

Structure of 2112738-13-1

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Description

Mal-amido-PEG2-Val-Cit-PAB-PNP features a cleavable Val-Cit dipeptide linker paired with a PAB-PNP payload, enabling site-specific conjugation via maleimide-thiol chemistry. This construct delivers high stability in circulation while ensuring efficient intracellular release, ideal for antibody-drug conjugate development.

Application

Mal-amido-PEG2-Val-Cit-PAB-PNP serves as a robust linker for antibody-drug conjugates, enabling site-specific payload attachment via maleimide-thiol chemistry. The PEG2 spacer enhances solubility and stability, while the Val-Cit dipeptide provides protease-sensitive cleavage in target cells. This construct facilitates efficient drug release and demonstrates compatibility with standard bioconjugation workflows.

General Information

CAS No. 2112738-13-1
Cat. No. CS-0115252
Purity ≥98%
MDL No. MFCD30828687
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃₉H₅₀N₈O₁₄
Molecular Weight 854.86
Synonym(s) None
SMILES O=C(NC1=CC=C(COC(OC2=CC=C(N(=O)=O)C=C2)=O)C=C1)[C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCNC(CCN(C3=O)C(C=C3)=O)=O)=O)=O

Computational Chemistry Data

TPSA 306.03
LogP 1.1776
H_Acceptors 14
H_Donors 6
Rotatable_Bonds 26

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

Quality Control

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Other Classifications

Life Science Linker Cleavable Linkers

Life Science Linker Maleimide Linkers

Life Science ADC Related Compound Cleavable Linker

Life Science ADC Related Compound Peptide/Protease Linker

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation Enzyme Cleavable Linkers (Cleave Motif)

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Enzyme Cleavable Linkers (Cleave Motif)

Key Words

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Mal-amido-PEG2-Val-Cit-PAB-PNP

CAS No. 2112738-13-1

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