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5-Chloropyrazine-2-carboxamide

  • CAS No. 21279-64-1

  • Cat. No. CS-W003733
  • Purity≥98%
  • MDL No.MFCD10686873

*For research and further manufacturing use only, not for direct human use.

5-Chloropyrazine-2-carboxamide|CS-W003733

Structure of 21279-64-1

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General Information

  • CAS No. 21279-64-1
  • Cat. No. CS-W003733
  • Purity ≥98%
  • MDL No. MFCD10686873
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClN₃O
  • Molecular Weight 157.56
  • Synonym(s) 2-Pyrazinecarboxamide, 5-chloro-
  • SMILES NC(=O)c1cnc(cn1)Cl

Description

5-Chloropyrazine-2-carboxamide is a heterocyclic amide featuring a chlorinated pyrazine core with a carboxamide group at the 2-position. This scaffold provides a rigid, electron-deficient platform suitable for integration into bioactive molecules. The compound exhibits enhanced solubility and stability under standard conditions, enabling efficient incorporation into medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.

Synthesis

  • Route1

    References

    • R-tech Ueno, Ltd. Patent: WO2009/145360 A1, 2009 ; Location in patent: Page/Page column 71 ; WO 2009/145360 A1
  • Route2
    • null|null
      88625-23-4
    • ~78%
    • In-stock
      5-Chloropyrazine-2-carboxamide|CS-W003733
      21279-64-1

    References

    • Cynamon, Michael H.; Speirs, Robert J.; Welch, John T. Antimicrobial Agents and Chemotherapy, 1998 , vol. 42, # 2 p. 462 - 463
  • Route3

    References

    • Dlabal, Karel; Palat, Karel; Lycka, Antonin; Odlerova, Zelmira Collection of Czechoslovak Chemical Communications, 1990 , vol. 55, # 10 p. 2493 - 2501

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   68.87
  • LogP   0.2289
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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