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CS-W001157 4
Total: USD 88.00

L-Azetidine-2-carboxylic acid

  • CAS No. 2133-34-8

  • Cat. No. CS-0031389
  • Purity≥95%
  • MDL No.MFCD00005166

*For research and further manufacturing use only, not for direct human use.

L-Azetidine-2-carboxylic acid|CS-0031389

Structure of 2133-34-8

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General Information

  • CAS No. 2133-34-8
  • Cat. No. CS-0031389
  • Purity ≥95%
  • MDL No. MFCD00005166
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇NO₂
  • Molecular Weight 101.10
  • Synonym(s) None
  • SMILES O=C([C@H]1NCC1)O

Description

Inducing embryonic malformations via misincorporation into nascent polypeptides, L-Azetidine-2-carboxylic acid (CAS 2133-34-8) disrupts protein folding fidelity and triggers cellular stress responses in developing tissues.

Application

L-Azetidine-2-carboxylic acid (CAS 2133-34-8) disrupts collagen synthesis by mimicking proline and integrating into nascent polypeptide chains, causing misfolding. This triggers aberrant protein conformation. Researchers rely on it as a standard in liquid chromatography-mass spectrometry workflows to validate peptide separation and detection accuracy.

Synthesis

  • Route1
    • (R)-4-Amino-2-chlorobutanoic acid|CS-0907571
      307316-14-9
    • ~%
    • In-stock
      L-Azetidine-2-carboxylic acid|CS-0031389
      2133-34-8

    References

    • EP1415985 A1, ; Page 9 ;
  • Route2
    • null|null
      247051-66-7
    • ~98%
    • In-stock
      L-Azetidine-2-carboxylic acid|CS-0031389
      2133-34-8

    References

    • Couty, Francois; Evano, Gwilherm; Vargas-Sanchez, Monica; Bouzas, Gloria Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 9028 - 9031
  • Route3
    • null|null
      69994-45-2
    • ~80%
    • In-stock
      L-Azetidine-2-carboxylic acid|CS-0031389
      2133-34-8

    References

    • Barrett, Anthony G. M.; Dozzo, Paola; White, Andrew J. P.; Williams, David J. Tetrahedron, 2002 , vol. 58, # 36 p. 7302 - 7314

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   -0.5671
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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