(5-Chloro-3-fluoropyridin-2-yl)methanol

Name: (5-Chloro-3-fluoropyridin-2-yl)methanol
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CAS No. 214055-12-6
Cat. No. CS-0054102
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(5-Chloro-3-fluoropyridin-2-yl)methanol|CS-0054102

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General Information

CAS No. 214055-12-6
Cat. No. CS-0054102
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClFNO
Molecular Weight 161.56
Synonym(s) (5-Chloro-3-fluoro-2-pyridinyl)methanol
SMILES OCC1=NC=C(Cl)C=C1F

Description

(5-Chloro-3-fluoropyridin-2-yl)methanol features a pyridine core functionalized with chlorine and fluorine at the 5- and 3-positions, respectively, and a reactive methanol group at the 2-position. This trifunctional scaffold enables direct incorporation into bioactive molecules, offering enhanced metabolic stability and targeted electronic modulation in pharmaceutical development.

Application

(5-Chloro-3-fluoropyridin-2-yl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated pyridine scaffolds. Its aldehyde functionality facilitates nucleophilic addition, reductive amination, and coupling reactions with broad functional group tolerance. The molecule exhibits bench stability and is readily purified by standard chromatographic methods, making it well-suited for multi-step synthesis and process development in API research.

Synthesis

Route1
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  214055-12-6
References
- IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y.; SPROTT, Kevin Patent: WO2012/88469 A1, 2012 ; WO 2012/088469 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 33.12
LogP 1.3664
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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(5-Chloro-3-fluoropyridin-2-yl)methanol

CAS No. 214055-12-6

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