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CS-W001157 4
Total: USD 88.00

6-Bromoquinazolin-4-amine

  • CAS No. 21419-48-7

  • Cat. No. CS-W018924
  • Purity≥95%
  • MDL No.MFCD02228849
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Bromoquinazolin-4-amine|CS-W018924

Structure of 21419-48-7

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Description

6-Bromoquinazolin-4-amine serves as a key intermediate in the synthesis of kinase inhibitors and pharmaceutical agents. This heterocyclic scaffold features a bromine substituent at the 6-position, enabling facile palladium-catalyzed cross-coupling reactions. The amine group at the 4-position facilitates derivatization through acylation, alkylation, or coupling with electrophiles, supporting rapid access to diverse quinazoline-based libraries under standard conditions.

Application

6-Bromoquinazolin-4-amine serves as a versatile building block for the synthesis of biologically active quinazoline derivatives. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, facilitating the construction of complex heterocyclic scaffolds. The amine group provides a site for derivatization via acylation or alkylation, enhancing functional group diversity. This compound exhibits good bench stability and is compatible with standard synthetic workflows in medicinal chemistry and process development.

General Information

  • CAS No. 21419-48-7
  • Cat. No. CS-W018924
  • Purity ≥95%
  • MDL No. MFCD02228849
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆BrN₃
  • Molecular Weight 224.06
  • Synonym(s) Quinazoline, 4-amino-6-bromo-
  • SMILES NC1=C2C=C(Br)C=CC2=NC=N1

Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.9745
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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