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Structure of 21419-48-7
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6-Bromoquinazolin-4-amine serves as a key intermediate in the synthesis of kinase inhibitors and pharmaceutical agents. This heterocyclic scaffold features a bromine substituent at the 6-position, enabling facile palladium-catalyzed cross-coupling reactions. The amine group at the 4-position facilitates derivatization through acylation, alkylation, or coupling with electrophiles, supporting rapid access to diverse quinazoline-based libraries under standard conditions.
6-Bromoquinazolin-4-amine serves as a versatile building block for the synthesis of biologically active quinazoline derivatives. Its bromine substituent enables palladium-catalyzed cross-coupling reactions, facilitating the construction of complex heterocyclic scaffolds. The amine group provides a site for derivatization via acylation or alkylation, enhancing functional group diversity. This compound exhibits good bench stability and is compatible with standard synthetic workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: