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Structure of 214360-49-3
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1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethan-1-one features a boronate ester group flanked by an electron-rich aryl ring and a ketone-bearing side chain. This structure enables reliable cross-coupling in palladium-catalyzed reactions under standard conditions. The tetramethyl-substituted dioxaborolane moiety enhances stability and resistance to hydrolysis during handling. Designed for efficient integration into complex molecular architectures, this reagent streamlines the synthesis of biaryl ketones in medicinal chemistry and materials science applications.
1-(3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethan-1-one serves as a versatile boron-containing building block for Suzuki-Miyaura cross-coupling reactions. The sterically hindered tetramethyl-substituted dioxaborolane moiety enhances stability and minimizes protodeboronation, enabling reliable coupling with aryl halides under mild conditions. Its ketone functionality provides orthogonal reactivity, facilitating downstream transformations such as reductions or nucleophilic additions. Ideal for constructing biaryl scaffolds in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: