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Structure of 214360-57-3
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N-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide features a boronate ester group flanked by electron-rich tetramethylcyclopentadienone rings, enabling robust coupling in Suzuki-Miyaura reactions. The N-methyl amide moiety enhances solubility and metabolic stability, while the bench-stable boronate resists hydrolysis under standard conditions. This compound integrates efficiently into complex molecular architectures with minimal side reactivity.
N-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide serves as a robust boronate building block for Suzuki-Miyaura cross-coupling reactions. Its stability under ambient conditions and tolerance to diverse functional groups enable efficient construction of biaryl scaffolds in medicinal chemistry and materials synthesis. The N-methyl amide moiety enhances solubility and metabolic stability, while the tetramethyl-substituted dioxaborolane ensures high reactivity and low protodeboronation.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: