CRBN ligand-660

Name: CRBN ligand-660
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CAS No. 2154343-28-7
Cat. No. CS-0527797
Molecule weight279.68
Purity≥97%
MDL No.MFCD34180705

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 2154343-28-7

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General Information

CAS No. 2154343-28-7
Cat. No. CS-0527797
Purity ≥97%
MDL No. MFCD34180705
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₀ClN₃O₃
Molecular Weight 279.68
Synonym(s) None
SMILES O=C1NC(=O)C(N2C(=O)C3=CC(Cl)=NC=C3C2)CC1

Description

This piperidine-dione scaffold integrates a chlorinated pyrrolopyridinone core, offering enhanced metabolic stability and favorable binding kinetics. The fused heterocycle enables precise spatial positioning in target-directed synthesis, while the carbonyl groups facilitate efficient conjugation strategies. Ideal for medicinal chemistry campaigns requiring rigid, electron-deficient platforms.

Application

3-(6-Chloro-1-oxo-1H-pyrrolo[3,4-c]pyridin-2(3H)-yl)piperidine-2,6-dione serves as a versatile building block for heterocyclic synthesis, enabling efficient access to complex pyrrolopyridine scaffolds. Its fused bicyclic core exhibits robust bench stability and tolerates diverse functional groups, facilitating downstream transformations in medicinal chemistry. The molecule functions effectively in coupling reactions and serves as a key intermediate in the development of bioactive compounds requiring rigid, planar architectures.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 79.37
LogP -0.3585
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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CRBN ligand-660

CAS No. 2154343-28-7

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