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Structure of 215918-21-1
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tert-Butyl (2S)-4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate is a stereodefined pyrrolidine derivative featuring a bench-stable tert-butyl carbamate protecting group and a hydroxymethyl side chain. The geminal difluoride moiety imparts enhanced metabolic stability and modulates electronic properties, enabling efficient incorporation into bioactive scaffolds. This building block facilitates the synthesis of fluorinated peptidomimetics and kinase inhibitors with improved membrane permeability.
tert-Butyl (2S)-4,4-difluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate serves as a stereochemically defined building block for fluorinated pyrrolidine scaffolds. The difluoro substitution enhances metabolic stability and modulates conformational flexibility, while the hydroxymethyl group enables downstream functionalization via oxidation or derivatization. The tert-butyl carbamate protects the nitrogen during synthesis, offering bench stability and ease of purification in multi-step sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: