(R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine hydrochloride

Name: (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine hydrochloride
Brand: ChemScene
Availability: InStock
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CAS No. 216002-20-9
Cat. No. CS-D0611
Purity≥97%
MDL No.MFCD03426128

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine hydrochloride|CS-D0611

Structure of 216002-20-9

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Description

(R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine hydrochloride delivers a chiral amine scaffold with enhanced stability and solubility. The electron-deficient aromatic ring improves binding affinity in asymmetric synthesis, while the hydrochloride salt ensures ease of handling and crystallinity. This bench-stable compound integrates readily into catalyst design and medicinal chemistry workflows.

Application

(R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine hydrochloride serves as a stable, bench-ready chiral building block for the synthesis of bioactive molecules. Its trifluoromethylated aromatic core enhances metabolic stability and lipophilicity, while the chiral amine functionality enables stereoselective transformations. The hydrochloride salt ensures excellent solubility and ease of handling, facilitating its use in standard coupling reactions, asymmetric synthesis, and API intermediate development.

General Information

CAS No. 216002-20-9
Cat. No. CS-D0611
Purity ≥97%
MDL No. MFCD03426128
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₀ClF₆N
Molecular Weight 293.64
Synonym(s) (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethylamine hydrochloride
SMILES FC(F)(F)C1=CC(C(F)(F)F)=CC([C@@H](C)N)=C1.Cl[H]

Computational Chemistry Data

TPSA 26.02
LogP 4.1657
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanamine hydrochloride

CAS No. 216002-20-9

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