Methyl 2-amino-5-(tert-butyl)thiophene-3-carboxylate

Name: Methyl 2-amino-5-(tert-butyl)thiophene-3-carboxylate
Brand: ChemScene
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CAS No. 216574-71-9
Cat. No. CS-0127739
Purity≥98%
MDL No.MFCD08059073

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Methyl 2-amino-5-(tert-butyl)thiophene-3-carboxylate|CS-0127739

Structure of 216574-71-9

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Description

Methyl 2-amino-5-(tert-butyl)thiophene-3-carboxylate features a sterically hindered tert-butyl group that enhances stability and solubility in organic media. The electron-rich thiophene core supports efficient coupling reactions, while the amino and ester functionalities enable direct incorporation into complex molecular architectures under standard conditions.

Application

Methyl 2-amino-5-(tert-butyl)thiophene-3-carboxylate serves as a versatile building block in heterocyclic synthesis, enabling efficient access to substituted thiophene scaffolds. The tert-butyl group provides steric protection and enhanced bench stability, while the amino and ester functionalities offer orthogonal reactivity for subsequent derivatization. This compound facilitates diverse transformations including Suzuki-Miyaura coupling, electrophilic substitution, and amide formation, making it valuable for medicinal chemistry and materials science applications.

General Information

CAS No. 216574-71-9
Cat. No. CS-0127739
Purity ≥98%
MDL No. MFCD08059073
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₅NO₂S
Molecular Weight 213.30
Synonym(s) Methyl 2-amino-5-tert-butylthiophene-3-carboxylate
SMILES O=C(C1=C(N)SC(C(C)(C)C)=C1)OC

Computational Chemistry Data

TPSA 52.32
LogP 2.4144
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Thiophene compounds

Key Words

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Methyl 2-amino-5-(tert-butyl)thiophene-3-carboxylate

CAS No. 216574-71-9

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